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And the 12 mg group lost 24.2%, with participants still losing weight at the end of the trial period, meaning the maximum effect had not been reached

Notably, further research is needed to determine whether PET MNPs compromise BBB integrity or pericyte-mediated intercellular signalling, which could ultimately affect barrier permeability and central nervous system exposure

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Those following a vegan or strict vegetarian lifestyle are at greater risk of deficiency and may benefit from regular B12 supplementation or injections